NMN & NAD-Anti-Aging Supplements and Why You Might Use Them

This article gives a brief overview of the promising supplements NMN and NAD+, which seem to hold a lot of promise for slowing down aging and supporting health generally.

NMN is a Vitamin B3 (niacin) derivative. It occurs naturally and can be made from dietary sources such as fruits, milk, and vegetables. In the body, NMN is used to generate NAD (nicotinamide adenine dinucleotide), a powerful and essential molecule that is found in every cell of the body. Believe it or not, it’s been said that if NAD levels in your body drop to zero, you’d be dead in about 30 seconds. NAD+ helps many important enzymes to carry out their functions, such as sirtuins and PARPs, which repair damaged DNA. A basic definition of nicotinamide adenine dinucleotide is a cofactor found in all living cells. It’s involved in energy metabolism and a number of bodily processes that allow life to be possible

It is also widely recognized that NMN is a potent precursor for NAD. Though NMN is naturally found in small amounts in fruits and vegetables such as avocados, broccoli, cabbage, edamame, and cucumbers ; in mammals most NMN is synthesized from vitamin B3 in the form of nicotinamide.

NMN levels fall with age, and aging itself has also been shown to significantly compromise the body’s conversion of NMN to NAD. By middle age, our NAD levels have plummeted to half that of our youth. According to an article published in Scientific America, “A prominent theory of aging holds that decaying of mitochondria is a key driver of aging.”

NMN can be taken orally; it’s well-absorbed and converted to NAD rapidly. It’s also much more stable in the gut lumen and bloodstream than other NAD boosters. In fact, recent studies show that NMN is likely the best NAD booster to impact aging. That’s why acclaimed aging specialists, like Harvard Professor David Sinclair, take NMN. Nicotinamide riboside (NR) is also another option to use as a precursor to NAD+.

Background

It all happened about 20 years ago at M.I.T (Massachusetts Institute of Technology) when Leonard Guarente, a biology professor, and a team of other scientists discovered SIRT1 genes (Sirtuins) in yeast. Sirtuins are molecules that maintain the epigenome.

The epigenome is the intricate molecular machinery that surrounds the DNA. The epigenome regulates which genes are switched on or off. It’s a very complex system, making sure that only gut genes are active in gut cells, and not in skin or brain cells for example.

As we get older, the epigenome becomes more dysfunctional. Genes that should be switched on are switched off, like housekeeping genes, while some genes are switched on that should be switched off, like cancer-promoting genes or pro-inflammatory genes.

NMN plays a crucial role in creating NAD+. When we have high levels of NAD+ in our bodies, cellular energy increases which becomes the fuel of life—powering every organ and cell in our bodies and protecting us from DNA damage. NAD+ also activates sirtuins which are essential in increasing our life expectancy and slowing down the aging process.

Sirtuins control aging: seven of them are found in humans and five in yeast. Essentially, they protect all organisms on the planet, including humans, from deterioration and disease. They work amongst many cellular pathways that control cell death, turn anti-aging genes on and off, helping repair DNA, and regulating metabolism.

When more of these genes (sirtuins) were put in organisms, the organisms’ lifespans extended by 5 to 20 percent. It was with this discovery that scientists began mimicking the genes using molecules. One of the molecules they used was NMN and the other, resveratrol.

As mitochondria lose some of their power, this seems to contribute to diseases and symptoms tied to aging, including heart failure, cognitive decline/neurodegeneration and fatigue. Supplementing with substances such as NMN, may help avoid some of these issues by directly supporting our mitochondrial function.

Doctors are even sometimes prescribing higher doses of NAD therapy for patients in the form of intramuscular (IM) or intravenous (IV) NAD injections. This type of treatment may be used to manage symptoms of Parkinson’s disease, dementia or depression, for example. We include this point not to recommend that but just to highlight that it is happening in some places. Higher protein diets will sometimes be enough to boost NAD production. One thing you should take note of- excessive alcohol intake can definitely negatively impact B vitamins, which affects your body’s production of NAD.

Conclusion

Although more human research is needed, based on the evidence available right now, which is mostly from mice and yeast studies, direct supplementation of NAD & NMN seem to help reverse or delay mitochondrial decay, repair DNA, and support healing of brain tissue, blood vessels and more. (4) (5)

Vitalita carries NMN here and NAD+ here

Suggested Use

Take NMN on an empty stomach first thing in the morning even if you’re fasting. Dosages are most often in the 400-600mg range. 1 gram a day is also a commonly used dosage that people have found benefits from.

REFERENCES

1) The Science Behind NMN–A Stable, Reliable NAD+Activator and Anti-Aging Molecule https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238909/

2) The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial https://pubmed.ncbi.nlm.nih.gov/36482258/

  1. https://blogs.scientificamerican.com/guest-blog/beyond-resveratrol-the-anti-aging-nad-fad/
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963347/
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973386/

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